Course From Gene to Function - Molecular Analysis of Disease Genes

From Gene to Function - Molecular Analysis of Disease Genes

Reg.no. C104/16

is being offered by the Graduate School of Health Sciences, University of Aarhus, autumn 2016.

Criteria for participation: University degree in medicine, dentistry, nursing, or Master’s degree in other fields and/or postgraduate research fellows (PhD students and research-year medical students).

Aim: Getting familiar with the theoretical background, the experimental methods, and interpretation of results in studies investigating consequences of mutations and molecular disease mechanism.

Learning outcome: After completion of the course the PhD student will achieve knowledge in:

• Theoretical assessment of potential effects of gene variations
• Protein structure folding and trafficking
• Methods for experimental investigations of effects of gene variations
• Use of recombinant DNA techniques
• Use of cellular and in vitro experiments

Contents: The course consists of a theoretical part (aprox. 70 %) including lectures, group exercises and a Journal Club, and 'hands-on' experimental exercises (aprox. 30 %). In the theoretical part we give an introduction to the knowledge on gene expression and protein biogenesis (trafficking, folding and degradation), design and evaluation of expression experiments aimed to investigate the effects of disease-associated gene variations and a brief general introduction to the use of Internet databases and data-mining in this context.
In the practical part model experiments exploring the biogenesis of disease-associated mutant proteins will be performed.

Language: English

ECTS: 2,9

Head of Course: Peter Bross

Instructors: Peter Bross, assoc. prof, PhD; Niels Gregersen prof. Dr.Med.; Cláudio Gomes, PhD; Johan Palmfeldt, PhD; Søren Vang, PhD; Anne Bie, PhD stud.; Brage Andersen, prof., Dr.Med. Rasha Al-Saaidi, cand. scient.

Number of Participants: Max 16 participants

Dates and Times: 21-24 November 2016

Place: Science Center Skejby

Course Fee: 3480 kr.

Participation in the course is without cost for:

• PhD students and research-year students (with enrollment letter) from Aarhus University
• PhD students from University of Helsinki
• PhD students from other institutions in the open market agreement for PhD courses

Application deadline: 26 September 2016

Application: https://service.health.au.dk/modules/Course/mypage/coursecalendar

Course dates:

• 21 November 2016