Course Bacterial infections in implants and bone

The course C307/02 Bacterial infections in implants and bone is being offered by the Graduate School of Health, Aarhus University, 2025.

Criteria for participation: University degree in medicine, dentistry, nursing, or Master’s degree in other fields and/or postgraduate research fellows (PhD students and research-year medical students).

Aim: To provide state-of-the-art knowledge regarding bacterial infections in implants and bone

Learning outcomes: 
Upon completion of this course, the students will be able to:
- Describe the aetiology of implant and bone infections
- Exemplify why bone infections are difficult to treat?
- Identify relevant preclinical models
- Describe basic pharmacokinetic/pharmacodynamic aspects of antibiotic treatment
- Acquire knowledge regarding state-of-the-art microbiological and histopathological analysis
- Plan, develop and present future relevant studies on bacterial infections in implants and bone

This course seeks to provide state-of-the-art knowledge regarding bacterial infections in implants and bone and introduces the important research steps and challenges of translating basic science ideas into clinical applications.

Workload: The full workload of the course is expected to be 20 hours

Content: 
Preliminary program:

Day 1

08.30 – 09.00: Welcome (MB + NPJ)
09.00 – 10.15: Persister cells and how to model biofilm infections in vivo (RM)
10.15 – 10.30: Coffee break
10.30 – 11.45: Animal models and histopathology (LK)
11.45 – 12.45: Lunch
12.45 – 14.00: The aetiology of bacterial implant and bone infections (TB)
14.00 – 14.15: Coffee break
14.15 – 15.30: Why are bacterial implant and bone infections difficult to treat?

Day 2

08.00 – 08.30: What we learned on day 1 (MB+NPJ)
08.30 – 09.30: Group work (MB+ NPJ)
09.30 – 10.30: Group presentation (MB+NPJ)
10.30-11.00: Coffee break
11.00-11.45: Bone and tissue penetration of antibiotics (MB)
11.45-1230: MDT-treatment of bacterial implant and bone infections (NPJ)
12.30 – 13.30: Lunch
13.30 – 15.00: Keynote talk – Bridging the gap from bench to bedside
15.00 – 15.30: End of course, evaluation (MB+NPJ)

Instructors: 
Mats Bue (MB), MD, PhD, Associate Professor
Department of Orthopaedic Surgery, Aarhus University Hospital
Department of Clinical Medicine, Aarhus University

Nis Pedersen Jørgensen (NPJ), MD, PhD, Post doc.
Department of Infectious Diseases, Aarhus University Hospital
Department of Clinical Medicine, Aarhus University

Instructors:
Rikke Louise Meyer (RM), PhD, Associate Professor, Aarhus University
Thomas Bjarnsholt (TB), Professor, PhD, Dr.med, Copenhagen University
Louise Kruse Jensen (LK), Professor, DVM, PhD, Copenhagen University

International speakers can/will be invited if possible, but not part of the current budget.

Venue: Aarhus University, Aarhus (other)

Participation in the course is without cost for:

• PhD students, Health Research Year students from Aarhus University
• PhD students enrolled at partner universities of the Nordoc collaboration
• PhD students from other institutions in the open market agreement for PhD courses

Course dates:

• 22 May 2025 08:30 - 15:30
• 23 May 2025 08:00 - 15:30